Overcome Syngap1
Overcôme Syngap1 aims at raising awareness on the SYNGAP1 genetic disorder, helping families affected by the disease and raising funds to find a cure.
Mutations of the SYNGAP1 gene in humans can cause intellectual disability and/or epilepsy. This gene is also related to autism.
The association currently supports:
Sainte Justine Hospital in Montreal
In 2016, we began supporting research at Sainte Justine Hospital (Professor Michaud’s teams) in Montreal. An article was published on the project that Mabel Carreno-Munoz presented to you during a webinar.
McGill University
Since 2022, we have been supporting another project at McGill University, led by Professor Bowie, to test an approach for targeting the molecular pathways underlying intellectual disability. This project is being developed in collaboration with the American organization Syngap Research Fund.
University of Ottawa
We are also helping to fund, in collaboration with Syngap Research Fund, the research work of Professor Baptiste Lacoste at the University of Ottawa to explore new aspects of the disease: how brain energy use and blood flow can affect symptoms. By discovering these links, this project could lead to more effective therapies or diagnostics that can make a real difference in the daily lives of patients and their caregivers, giving families hope for a better future.
Research in France (IINS of Bordeaux)
A research project with the Interdisciplinary Institute of Neurosciences of Bordeaux, Professor Choquet’s department, and particularly Eric Hosy’s team which has been leading fundamental work on SynGAP1 pathology since 2020, on the role and effects of mutations of the SynGAP1 protein on synapse function.
The EURAS research project
Identify patients
To identify all SynGAP1 patients in Europe by collecting medical information to provide homogeneous data for scientific studies.
Conduct research
To conduct fundamental research to identify the biological effects of the SynGAP1 mutation.
Test treatments
To test which of the drugs available on the market could have a beneficial effect on SynGAP1 symptoms.
Stay in touch
If your child has SynGAP1, you’ve probably already been asked to take part in this study.
Find out about our global network: https://www.syngapglobal.net/